Can Estrogen Therapy Treat Depression During Perimenopause?

During perimenopause, shifting hormone levels—especially drops and fluctuations in estrogen—can disrupt brain chemistry and trigger or worsen depression. While antidepressants are often the first treatment choice, many women find only partial relief. Research shows that estrogen therapy, alone or combined with antidepressants, may help improve mood, reduce anxiety, and ease other menopause-related symptoms. However, hormone therapy isn’t right for everyone, and decisions should be based on personal health history, risks, and preferences. This article explores the science, benefits, and considerations of using estrogen therapy to treat depression during the menopause transition.